In December 2007, we entered into an agreement with Memorial Sloan-Kettering Cancer
Center (MSKCC) to exclusively license certain rights to the investigational monoclonal
antibody, 8H9, for the treatment of metastatic brain cancer. The monoclonal antibody
8H9 is a mouse IgG1 antibody with specificity for the B7H3 antigen. The 8H9 antibody
is highly reactive with a range of human solid tumors, including human brain cancers.
The 8H9 antibody is in early investigational development for metastases which develop
in the brain from the spread of cancers from other tissues in the body. Metastatic
brain cancers are ten times more common than cancers that originate in the brain,
and prognosis is very poor. In the United States, more than 100,000 cases of metastatic
brain cancer are diagnosed each year.